Product Configurator Performance 8.03.409A

We are running version 8.03.409A and are heavily dependent on product configurator. Ever since going to the current version we occasionally, about once every two weeks, run into product configurator performance problems in the Opportunity/Quote screen. Our configs usually take between 10 and 15 seconds to save. When we notice that performance is poor that time jumps to 5 to 8 minutes. The fix for the problem is a server reboot.

I have tried numerous things to troubleshoot the problem such as disabling all BPMs and running the Quote screen without our normal customizations applied, none of these steps improve the time it takes to save the config. No other modules or screens in Vantage notice any type of performance hits while the configurator is slow in quoting. Also, watching the performance monitor on the server gives no indication that there is anything unusual going on.

Has anyone else experienced something similar?