F5 Load Balancer set up

Anyone using an F5 load balancer set up for the appservers?  We've just implemented this and had no issues on our Pilot/Test environments but now that it is in the Live environment we're finding some users are getting the wonderful 7224 errors (Tried to call a method in an invalid procedure) and 7175 errors(Communication Error Message: Error Marshalling or Unmarshalling Appserver Message).

Anything additional you had to do epicor wise or in particular?