Microsoft has replaced System.Configuration class with IConfiguration interface in .Net Core, or requires you to include it yourself via nuget.
.NET (Core) does not use AppDomain at all. - @Olga
Unsure of the right syntax, but if you spin up Visual Studio, see if you can make a basic .NET 6 Console Application to read an xml.
I think the .NET 6 Core is IConfiguration:
Example App:
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