Couple of comments from the peanut gallery…
Starting with 2022.1, the Server is running .NET 6 which requires some additional steps to enable WCF based integrated applications - primarily applications not using REST and not using the Client components for connectivity to the Server Services. You essentially need to register in the database each Business Object Service that you want to access via an application expecting to call a WCF based endpoint. Once the BO Services have been registered, the AppServer needs to be restarted.
Included with the 2022+ Release is a SQL Script that can be used to register the standard BO Services used by Epicor provided applications like HCM and the ECM v1 (SOAP) integration. Please reference EpicCare KB Article KB0120930 for more details.
As part of the move to .NET 6, most of the configuration elements previously found in Web.config are now located in Host.config.